Acenocoumarol
Adverse Effect: increased risk of bleeding Clinical Management: Concurrent use of Danazol and Acenocoumarol should be avoided when possible. When use of this combination of drugs cannot be avoided, frequent monitoring of the prothrombin time is necessary until any effect on the anticoagulant response has been manifest and is stabilized at an acceptable level.
Carbamazepine
Adverse Effect: carbamazepine toxicity (ataxia, nystagmus, diplopia, headache, vomiting, apnea, seizures, coma) Clinical Management: Monitor for symptoms of carbamazepine toxicity when danazol is added to therapy. Serum carbamazepine levels should also be considered with the addition or discontinuation of danazol and dosage adjustments made accordingly.
Cyclosporin
Adverse Effect: Increases Cyclosporine concentrations Clinical Management: Monitor Cyclosporine concentrations and adjust the dosage accordingly.
Phenindione
Adverse Effect: increased risk of bleeding Clinical Management: Concurrent use of Danazol and Phenindione should be avoided when possible. When use of this combination of drugs cannot be avoided, frequent monitoring of the prothrombin time is necessary until any effect on the anticoagulant response has been manifest and is stabilized at an acceptable level.
Warfarin
Adverse Effect: increased risk of bleeding Clinical Management: Concurrent use of Danazol and Warfarin should be avoided when possible. When use of this combination of drugs cannot be avoided, frequent monitoring of the prothrombin time is necessary until any effect on the anticoagulant response has been manifest and is stabilized at an acceptable level. |